Gene Overdosage and comorbidities during the early lifetime in Down Syndrome

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8 March 2024

GO-DS21 Events before and on World Down Syndrome Day (WDSD) 2024

Patients and relatives, we are cordially inviting you to attend the following events during the coming weeks to celebrate and support World Down Syndrome Day 2024 (21 March because of 3 copies of chromosome 21 - hence month 3, day 21): The Association Française pour la Recherche sur la Trisomie 21 (AFRT) is organizing a French conference on “Aging Better with Down Syndrome” in Paris on Friday, 15 March (15:30 - 18:00 h) and Saturday, 16 March (9:00 - 17:30 h). In the United Kingdom, people and relatives affected by Down Syndrome are invited to come to The Francis Crick Institute in London on Saturday, 16 March, from 11:00 - 16:00 h. In Spain, the Parc de Recerca Biomèdica de Barcelona (PRBB) is hosting a fun and interactive event in Barcelona on Saturday, 16 March, starting at 10:30 h. Another event takes place at the Institut de Génétique, Biologie Moléculaire et Cellulaire (IGBMC) in Illkirch, France, on Thursday, 21 March, from 14:00 - 17:15 h. It is co-hosted by GO-DS21 coordinator Yann Hérault. Spread the news, help us overcome stereotypes, and post pictures and updates on social media about these events by using the hashtags #LotsOfSocks and #WorldDownSyndromeDay!

News & Events

More news
8 March 2024

GO-DS21 Events before and on World Down Syndrome Day (WDSD) 2024

Patients and relatives, we are cordially inviting you to attend the following events during the coming weeks to celebrate and support World Down Syndrome Day 2024 (21 March because of 3 copies of chromosome 21 - hence month 3, day 21): The Association Française pour la Recherche sur la Trisomie 21 (AFRT) is organizing a French conference on “Aging Better with Down Syndrome” in Paris on Friday, 15 March (15:30 - 18:00 h) and Saturday, 16 March (9:00 - 17:30 h). In the United Kingdom, people and relatives affected by Down Syndrome are invited to come to The Francis Crick Institute in London on Saturday, 16 March, from 11:00 - 16:00 h. In Spain, the Parc de Recerca Biomèdica de Barcelona (PRBB) is hosting a fun and interactive event in Barcelona on Saturday, 16 March, starting at 10:30 h. Another event takes place at the Institut de Génétique, Biologie Moléculaire et Cellulaire (IGBMC) in Illkirch, France, on Thursday, 21 March, from 14:00 - 17:15 h. It is co-hosted by GO-DS21 coordinator Yann Hérault. Spread the news, help us overcome stereotypes, and post pictures and updates on social media about these events by using the hashtags #LotsOfSocks and #WorldDownSyndromeDay!

Summary Statement

Clinicians, pathophysiologists, integrative bioinformaticians and artificial intelligence computer scientists working to unravel intrinsic and extrinsic mechanisms that impact on Down Syndrome (DS) comorbidity (focusing on obesity and intellectual disability. The examination of the pathways and mechanisms involved in comorbidities and multi-morbidities that induce the coexistence of two or more diseases in an individual is of major importance for the effective treatment of patients suffering from DS, obesity and mental disorders.

To achieve a system view to this disease we will integrate multiple datasets using new multi-layered approaches, which offer a unique opportunity for the integration and synthesis of molecular (multi-OMICS) preclinical (cellular and animal) and clinical datasets and metadata (environment, patient history) to understand the mechanisms of comorbidities.

In GO-DS21 we plan to use publicly available and self-developed bioinformatics tools, network science, statistical machine learning software and mathematical modeling approaches to unravel the shared etiological mechanisms in DS and the associated comorbidities, mainly obesity and intellectual disability.

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