Gene Overdosage and comorbidities during the early lifetime in Down Syndrome

Explore

News & Events

More news
21 September 2022

GO-DS21 - A pan-European research project addressing common Down Syndrome comorbidities

Watch the GO-DS21 consortium members explain in this video an ambitious pan-European project that investigates the underlying mechanisms and etiology of common Down Syndrome (DS) comorbidities.

Clinicians, pathophysiologists, integrative bioinformaticians, and artificial intelligence computer scientists working to unravel intrinsic and extrinsic mechanisms that impact DS comorbidity (focusing on obesity and intellectual disability). The examination of the pathways and mechanisms involved in comorbidities and multi-morbidities that induce the coexistence of two or more diseases in an individual is of major importance for the effective treatment of patients suffering from DS, obesity, and mental disorders.

Click here to view the video

News & Events

More news
21 September 2022

GO-DS21 - A pan-European research project addressing common Down Syndrome comorbidities

Watch the GO-DS21 consortium members explain in this video an ambitious pan-European project that investigates the underlying mechanisms and etiology of common Down Syndrome (DS) comorbidities.

Clinicians, pathophysiologists, integrative bioinformaticians, and artificial intelligence computer scientists working to unravel intrinsic and extrinsic mechanisms that impact DS comorbidity (focusing on obesity and intellectual disability). The examination of the pathways and mechanisms involved in comorbidities and multi-morbidities that induce the coexistence of two or more diseases in an individual is of major importance for the effective treatment of patients suffering from DS, obesity, and mental disorders.

Click here to view the video

Summary Statement

Clinicians, pathophysiologists, integrative bioinformaticians and artificial intelligence computer scientists working to unravel intrinsic and extrinsic mechanisms that impact on Down Syndrome (DS) comorbidity (focusing on obesity and intellectual disability. The examination of the pathways and mechanisms involved in comorbidities and multi-morbidities that induce the coexistence of two or more diseases in an individual is of major importance for the effective treatment of patients suffering from DS, obesity and mental disorders.

To achieve a system view to this disease we will integrate multiple datasets using new multi-layered approaches, which offer a unique opportunity for the integration and synthesis of molecular (multi-OMICS) preclinical (cellular and animal) and clinical datasets and metadata (environment, patient history) to understand the mechanisms of comorbidities.

In GO-DS21 we plan to use publicly available and self-developed bioinformatics tools, network science, statistical machine learning software and mathematical modeling approaches to unravel the shared etiological mechanisms in DS and the associated comorbidities, mainly obesity and intellectual disability.

Learn More

Our vision

Learn more

Why it matters

Learn more