Gene Overdosage and comorbidities during the early lifetime in Down Syndrome

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3 May 2024

GO-DS21 6th General Assembly Meeting

In one month from now, the 6th General Assembly meeting of the GO-DS21 will take place in the picturesque city of Rome from 2-4th of June 2024. Consortium partners will gather to discuss progress on the work since last meeting and give the chance to external advisors to provide their input in order to move the project forward.

News & Events

More news
3 May 2024

GO-DS21 6th General Assembly Meeting

In one month from now, the 6th General Assembly meeting of the GO-DS21 will take place in the picturesque city of Rome from 2-4th of June 2024. Consortium partners will gather to discuss progress on the work since last meeting and give the chance to external advisors to provide their input in order to move the project forward.

Summary Statement

Clinicians, pathophysiologists, integrative bioinformaticians and artificial intelligence computer scientists working to unravel intrinsic and extrinsic mechanisms that impact on Down Syndrome (DS) comorbidity (focusing on obesity and intellectual disability. The examination of the pathways and mechanisms involved in comorbidities and multi-morbidities that induce the coexistence of two or more diseases in an individual is of major importance for the effective treatment of patients suffering from DS, obesity and mental disorders.

To achieve a system view to this disease we will integrate multiple datasets using new multi-layered approaches, which offer a unique opportunity for the integration and synthesis of molecular (multi-OMICS) preclinical (cellular and animal) and clinical datasets and metadata (environment, patient history) to understand the mechanisms of comorbidities.

In GO-DS21 we plan to use publicly available and self-developed bioinformatics tools, network science, statistical machine learning software and mathematical modeling approaches to unravel the shared etiological mechanisms in DS and the associated comorbidities, mainly obesity and intellectual disability.

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