Gene Overdosage and comorbidities during the early lifetime in Down Syndrome

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2 February 2024

GO-DS21 8th Steering Committee meeting

Mark your calendars for the upcoming GO-DS21 8th Steering Committee meeting, taking place in the picturesque city of London from 18th to 20th February 2024. We look forward to all work package progress reports and in-depth discussion within the committee.

News & Events

More news
2 February 2024

GO-DS21 8th Steering Committee meeting

Mark your calendars for the upcoming GO-DS21 8th Steering Committee meeting, taking place in the picturesque city of London from 18th to 20th February 2024. We look forward to all work package progress reports and in-depth discussion within the committee.

Summary Statement

Clinicians, pathophysiologists, integrative bioinformaticians and artificial intelligence computer scientists working to unravel intrinsic and extrinsic mechanisms that impact on Down Syndrome (DS) comorbidity (focusing on obesity and intellectual disability. The examination of the pathways and mechanisms involved in comorbidities and multi-morbidities that induce the coexistence of two or more diseases in an individual is of major importance for the effective treatment of patients suffering from DS, obesity and mental disorders.

To achieve a system view to this disease we will integrate multiple datasets using new multi-layered approaches, which offer a unique opportunity for the integration and synthesis of molecular (multi-OMICS) preclinical (cellular and animal) and clinical datasets and metadata (environment, patient history) to understand the mechanisms of comorbidities.

In GO-DS21 we plan to use publicly available and self-developed bioinformatics tools, network science, statistical machine learning software and mathematical modeling approaches to unravel the shared etiological mechanisms in DS and the associated comorbidities, mainly obesity and intellectual disability.

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