Publications

GO-DS21 Publications

• Souchet B, Audrain M, Yu Y, Lindberg MF, Orefice NS, Rey E, Cartier N, Janel N, Meijer L, Braudeau J. (2022)
  ‍Cerebral phospho-tau acts synergistically with soluble Aβ42 leading to Mild Cognitive Impairment in AAV-AD rats
  J Prev Alzheimers Dis.
• Tahtouh T, Durieu E, Villiers B, Bruyère C, Nguyen TL, Fant X, Ahn KH, Khurana L, Deau E, Lindberg M, Sévère E, Miège F, Roche D, Limanton E, L’helgoual’ch JM, Burgy G, Guihéneuf S, Hérault Y, Kendall DA, Carreaux F, Bazureau JP, Meijer L. (2022)
  ‍Structure/activity relationship in the Leucettine family of kinase inhibitors
  J. Med. Chem., 65, 2, 1396–1417.
• Bourhala K, Guihéneuf S, Limanton E, Paquin L, Durieu E, Lozach O, Le Guével R, Charlier T, Rahmouni M, Carreaux F, Meijer L, Bazureau JP. (2021)
  ‍Design and microwave synthesis of new (5Z) 5-arylidene-2-thioxo-1,3-thiazoline-4-one and (5Z) 2-amino-5-arylidene-1,3-thiazol-4(5H)-one as new inhibitors of the protein kinase DYRK1A
  Pharmaceuticals, 14(11), 1086.
• Brault V, Nguyen TL, Flores-Gutiérrez J, Iacono G, Birling MC, Lalanne V, Meziane H, Manousopoulou A, Pavlovic G, Lindner L, Selloum M, Sorg T, Yu E, Garbis SD, Hérault Y. (2021)
  ‍Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome
  PLoS Genet, 17(9): e1009777.
• D’Agostino D, Liò P, Aldinucci M, Merelli I. (2021)
  ‍Advantages of using graph databases to explore chromatin conformation capture experiments
  BMC Bioinformatics, 22 (Suppl 2).
• De Toma I, Sierra C, Dierssen M. (2021)
  ‍Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in Down syndrome
  PLoS Comput Biol, 17(9): e1009317.
• Duchon A, del Mar Muniz Moreno M, Martin Lorenzo S, Silva de Souza MP, Chevalier C, Nalesso V, Meziane H, de Sousa PL, Noblet V, Armspach J, Brault V, Herault Y. (2021)
  ‍Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models
  Human Molecular Genetics, Volume 30, Issue 9, 1 May 2021, Pages 771–788.
• Espeso-Gil S, Holik AZ, Bonnin S, Jhanwar S, Chandrasekaran S, Pique-Regi R, Albaigès-Ràfols J, Maher M, Permanyer J, Irimia M, Friedländer MR, Pons-Espinal M, Akbarian S, Dierssen M, Maass PG, Hor CN, Ossowski S. (2021)
  ‍Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition
  Front. Mol. Neurosci.,14:664912.
• Hüls A, Costa ACS, Dierssen M, Baksh RA, Bargagna S, Baumer NT, et al. (2021)
  ‍Medical vulnerability of individuals with Down syndrome to severe COVID-19–data from the Trisomy 21 Research Society and the UK ISARIC4C survey
  EClinical Medicine, VOLUME 33, 100769, March 01, 2021.
• Lindberg M, Meijer L. (2021)
  ‍Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases (CLKs) in human disease, an overview
  Int. J. Mol. Sci., 22(11), 6047.
• Lindberg MF, Meijer L. (2021)
  ‍Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview
  Int. J. Mol. Sci., 22(11), 6047.
• Real de Asua D, Mayer MA, del Carmen Ortega M, Borrel JM, de Jesús Bermejo T, González-Lamuño D, Manso C, Moldenhauer F, Carmona-Iragui M, Hüls A, Sherman SL, Strydom A, de la Torre R, Dierssen M on behalf of the Spanish Trisomy 21 Research Society COVID-19 Taskforce. (2021)
  ‍Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome
  J. Clin. Med., 10(16), 3748.
• Sierra C, De Toma I, Cascio LL, Vegas E, Dierssen M. (2021)
  ‍Social Factors Influence Behavior in the Novel Object Recognition Task in a Mouse Model of Down Syndrome
  Front Behav Neurosci, 15: 772734.
• Barbiero P, Lio P. (2020)
  ‍The computational patient has diabetes and a Covid
  medRxiv.
• De Toma I, Ortega M, Catuara-Solarz S et al. (2020)
  ‍Re-establishment of the epigenetic state and rescue of kinome deregulation in Ts65Dn mice upon treatment with green tea extract and environmental enrichment
  Sci Rep, 10:16023.
• Dierssen M, Fructuoso M, Martínez de Lagrán M, Perluigi M and Barone E. (2020)
  ‍Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions
  Front. Neurosci., 14:670.
• Fernández-Blanco A, Dierssen M. (2020)
  ‍Rethinking Intellectual Disability from Neuro- to Astro-Pathology
  Int. J. Mol. Sci., 21(23), 9039.
• Kaspar D, Hastreiter S, Irmler M, Hrabé de Angelis M, Beckers J. (2020)
  ‍Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations
  Mamm Genome, 31, 119–133 (2020).

Background Literature

Coming soon!