Publications

GO-DS21 Publications

• Baksh R, Pape S, Chan L, Aslam A, Gulliford M, Strydom A. (2023)
  ‍Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: a population-based cohort study using electronic health records
  The Lancet Public Health, 2468-2667.
• Lindberg M, Deau E, Arfwedson J, George N, George P, Alfonso P, Meijer L. (2023)
  ‍Comparative efficacy and selectivity of pharmacological inhibitors of DYRK and CLK protein kinases
  J. Med. Chem. 66, 4106-4130
• Aslam A, Baksh A, Pape S, Strydom A, Gulliford M, Chan L. (2022)
  ‍Diabetes and Obesity in Down Syndrome Across the Lifespan: A Retrospective Cohort Study Using U.K. Electronic Health Records
  Diabetes Care 1, 45 (12): 2892–2899.
• Baksh R A, Strydom A, Pape S E, Chan L F, Gulliford M C. (2022)
  ‍Susceptibility to COVID-19 Diagnosis in People with Down Syndrome Compared to the General Population: Matched-Cohort Study Using Primary Care Electronic Records in the UK
  J Gen Intern Med, 37.
• Costa A, Brandao A C, Real de Asua D, Strydom A, Lunsky Y, Ghosh S, Chicoine B, Sgandurra G, Carfì A, Levin J, Hüls A, Lakhanpaul M. (2022)
  ‍COVID-19 vaccination of individuals with Down syndrome-data from the trisomy 21 Research Society Survey on Safety, Efficacy, and Factors Associated with the Decision to be Vaccinated
  Vaccines, 10(4):530.
• Duchon A, del Mar Muñiz Moreno M, Chevalier C, Nalesso V, Andre P, Fructuoso-Castellar M, Mondino M, Po C, Noblet V, Birling M-C, Potier M-C, Herault Y. (2022)
  ‍Ts66Yah, a mouse model of Down syndrome with improved construct and face validity
  Dis Model Mech, 15 (12): dmm049721.
• Pinku H, Hüls A, Feany P T, Baumer N, Dierssen M, Bargagna S, Costa A C S, Chicoine B A, Rebillat A-S, Sgandurra G, Valentini D, Rohrer R T, Levin J, Lakhanpaul M, Carfì A, Sherman S L, Strydom, A, Ghosh S. (2022)
  ‍Differences in clinical presentation, severity, and treatment of COVID-19 among individuals with Down syndrome from India and high-income countries: Data from the Trisomy 21 Research Society survey
  Journal of Global Health.
• Souchet B, Audrain M, Yu Y, Lindberg MF, Orefice NS, Rey E, Cartier N, Janel N, Meijer L, Braudeau J. (2022)
  ‍Cerebral phospho-tau acts synergistically with soluble Aβ42 leading to Mild Cognitive Impairment in AAV-AD rats
  J Prev Alzheimers Dis.
• Atas-Ozcan H, Brault V, Duchon A, Herault Y. (2021)
  ‍Dyrk1a from Gene Function in Development and Physiology to Dosage Correction across Life Span in Down Syndrome
  Pubmed 11.
• Baksh R A, Pape S E, Smith J, Strydom A. (2021)
  ‍Understanding inequalities in COVID-19 outcomes following hospital admission for people with intellectual disability compared to the general population: a matched cohort study in the UK
  BMJ Open, 11:e052482.
• Bourhala K, Guihéneuf S, Limanton E, Paquin L, Durieu E, Lozach O, Le Guével R, Charlier T, Rahmouni M, Carreaux F, Meijer L, Bazureau JP. (2021)
  ‍Design and microwave synthesis of new (5Z) 5-arylidene-2-thioxo-1,3-thiazoline-4-one and (5Z) 2-amino-5-arylidene-1,3-thiazol-4(5H)-one as new inhibitors of the protein kinase DYRK1A
  Pharmaceuticals, 14(11), 1086.
• Brault V, Nguyen TL, Flores-Gutiérrez J, Iacono G, Birling MC, Lalanne V, Meziane H, Manousopoulou A, Pavlovic G, Lindner L, Selloum M, Sorg T, Yu E, Garbis SD, Hérault Y. (2021)
  ‍Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome
  PLoS Genet, 17(9): e1009777.
• D’Agostino D, Liò P, Aldinucci M, Merelli I. (2021)
  ‍Advantages of using graph databases to explore chromatin conformation capture experiments
  BMC Bioinformatics, 22 (Suppl 2).
• De Toma I, Sierra C, Dierssen M. (2021)
  ‍Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in Down syndrome
  PLoS Comput Biol, 17(9): e1009317.
• Duchon A, del Mar Muniz Moreno M, Martin Lorenzo S, Silva de Souza MP, Chevalier C, Nalesso V, Meziane H, de Sousa PL, Noblet V, Armspach J, Brault V, Herault Y. (2021)
  ‍Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models
  Human Molecular Genetics, Volume 30, Issue 9, 1 May 2021, Pages 771–788.
• Emes D, Hüls A, Bäumer N, Dierssen M, Puri S, Russell L A, Sherman S L, Strydom A, Bargagna S, Brandão A C, Costa A C S, Feany P T, Chicoine B, Ghosh S, Rebillat A-S, Sgandurra G, Valentini D, Rohrer T R, Levin J, Lakhanpaul M. (2021)
  ‍COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey
  Journal of Clinical Medicine, 10(21):5125.
• Espeso-Gil S, Holik AZ, Bonnin S, Jhanwar S, Chandrasekaran S, Pique-Regi R, Albaigès-Ràfols J, Maher M, Permanyer J, Irimia M, Friedländer MR, Pons-Espinal M, Akbarian S, Dierssen M, Maass PG, Hor CN, Ossowski S. (2021)
  ‍Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition
  Front. Mol. Neurosci.,14:664912.
• Hüls A, Costa ACS, Dierssen M, Baksh RA, Bargagna S, Baumer NT, et al. (2021)
  ‍Medical vulnerability of individuals with Down syndrome to severe COVID-19–data from the Trisomy 21 Research Society and the UK ISARIC4C survey
  EClinical Medicine, VOLUME 33, 100769, March 01, 2021.
• Lindberg M, Meijer L. (2021)
  ‍Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases (CLKs) in human disease, an overview
  Int. J. Mol. Sci., 22(11), 6047.
• Martinez de Lagran M, Elizalde‐Torrent A, Paredes R, Clotet B, Dierssen M. (2021)
  ‍Lamivudine, a Reverse Transcriptase Inhibitor, Rescues Cognitive Deficits in a Mouse Model of Down Syndrome
  Crossref, 10.
• Real de Asua D, Mayer MA, del Carmen Ortega M, Borrel JM, de Jesús Bermejo T, González-Lamuño D, Manso C, Moldenhauer F, Carmona-Iragui M, Hüls A, Sherman SL, Strydom A, de la Torre R, Dierssen M on behalf of the Spanish Trisomy 21 Research Society COVID-19 Taskforce. (2021)
  ‍Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome
  J. Clin. Med., 10(16), 3748.
• Sierra C, De Toma I, Cascio LL, Vegas E, Dierssen M. (2021)
  ‍Social Factors Influence Behavior in the Novel Object Recognition Task in a Mouse Model of Down Syndrome
  Front Behav Neurosci, 15: 772734.
• Barbiero P, Lio P. (2020)
  ‍The computational patient has diabetes and a Covid
  medRxiv.
• De Toma I, Ortega M, Catuara-Solarz S et al. (2020)
  ‍Re-establishment of the epigenetic state and rescue of kinome deregulation in Ts65Dn mice upon treatment with green tea extract and environmental enrichment
  Sci Rep, 10:16023.
• Dierssen M, Fructuoso M, Martínez de Lagrán M, Perluigi M and Barone E. (2020)
  ‍Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions
  Front. Neurosci., 14:670.
• Fernández-Blanco A, Dierssen M. (2020)
  ‍Rethinking Intellectual Disability from Neuro- to Astro-Pathology
  Int. J. Mol. Sci., 21(23), 9039.
• Kaspar D, Hastreiter S, Irmler M, Hrabé de Angelis M, Beckers J. (2020)
  ‍Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations
  Mamm Genome, 31, 119–133 (2020).

Background Literature

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