Prof. André Strydom
King’s College London (KCL) is one of the top 20 universities in the world and currently involved in ~200 European Commission projects. KCL attracts the best clinical academics to pioneer world-leading advances in health and well-being and has some 6,800 staff and more than 27,600 students from 150 countries worldwide. It has an outstanding reputation for world-class teaching and cutting-edge research. The Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at KCL is Europe’s largest centre for research in these fields with the highest combined citations outside the US and the most prominent research power for Psychology, Psychiatry and Neuroscience nationally. A key strength of the IoPPN is the close association between academic and clinical disciplines and in partnership; we host the NIHR Maudsley Biomedical Research Centre (BRC) which is also a member of King’s Health Partners, an Academic Health Sciences Centre (AHSC) that is a pioneering global collaboration translating cutting-edge research and existing best practice into excellent patient care.
Within GO-DS21, will we will lead WP1 by conducting both a retrospective cohort study using primary care data (from the CPRD dataset) as well as an in-depth phenotyping study in collaboration with other GO-DS21 clinical partners to determine age-related comorbidity patterns (with a focus on obesity) observed over the lifetime in persons with Down syndrome, collecting samples that will be used in WP5 to explore regulatory and epigenetic signatures. This data will be integrated in WP6 using computational biology models and machine learning approaches. We will also help to establish recommendations and targeted interventions to prevent or minimise comorbidities in persons with DS (WP7).